Search results for "acute respiratory distress syndrome"

showing 10 items of 30 documents

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial.

2012

Abstract Background Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with …

Research designARDSmedicine.medical_specialtyTime FactorsVentilator-Induced Lung InjuryAlveolar recruitmentTreatment outcomeRandomizedMedicine (miscellaneous)Settore MED/41 - AnestesiologiaHospital mortalitylaw.inventionPositive-Pressure RespirationStudy ProtocolMechanical ventilationClinical trialsRandomized controlled trialClinical ProtocolslawMedicineHumansPharmacology (medical)Hospital MortalityPEEPProtocol (science)Respiratory Distress SyndromeAcute respiratory distress syndromebusiness.industryrespiratory systemLength of Staymedicine.diseaseClinical trialPulmonary AlveoliARDS; Alveolar recruitment; PEEPIntensive Care UnitsTreatment OutcomeMulticenter studyBarotraumaResearch DesignPhysical therapyARDSbusinessBrazilTrials
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Experimental lung injury induces cerebral cytokine mRNA production in pigs

2020

Background Acute respiratory distress syndrome (ARDS) is an important disease with a high incidence among patients admitted to intensive care units. Over the last decades, the survival of critically ill patients has improved; however, cognitive deficits are among the long-term sequelae. We hypothesize that acute lung injury leads to upregulation of cerebral cytokine synthesis. Methods After approval of the institutional and animal care committee, 20 male pigs were randomized to one of three groups: (1) Lung injury by oleic acid injection (OAI), (2) ventilation only (CTR) or (3) untreated. We compared neuronal numbers, proportion of neurons with markers for apoptosis, activation state of Ib…

ARDSmedicine.medical_specialtyEmergency and Critical Caremedicine.medical_treatmentLung injuryGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineInternal medicineIntensive caremedicineCognitive declineCognitive DisordersRespiratory MedicineMicrogliaAcute respiratory distress syndromebusiness.industryGeneral Neuroscience030208 emergency & critical care medicineGeneral Medicinemedicine.diseaseLung injuryCritical careEndocrinologyCytokinemedicine.anatomical_structureCognitive impairmentNeurologyApoptosisCerebral inflammationCytokinesTumor necrosis factor alphaPigsGeneral Agricultural and Biological Sciencesbusiness030217 neurology & neurosurgeryPeerJ
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Acute Respiratory Distress Syndrome Associated with Tumor Lysis Syndrome in a Child with Acute Lymphoblastic Leukemia

2015

Tumor lysis syndrome is a serious and dangerous complication usually associated with antiblastic treatment in some malignancies characterized by high cell turn-over. Mild or severe electrolyte abnormalities including high serum levels of uric acid, potassium, phosphorus, creatinine, bun and reduction of calcium can be responsible for multi-organ failure, involving mostly kidneys, heart and central nervous system. Renal damage can be followed by acute renal failure, weight gain, progressive liver impairment, overproduction of cytokines, and subsequent maintenance of multi-organ damage. Life-threatening acute respiratory failure associated with tumor lysis syndrome is rare. We describe a chil…

Central nervous systemlcsh:MedicineCase ReportAcute respiratory distressacute lymphoblastic leukemiaPediatricschemistry.chemical_compoundmedicineacute respiratory distress syndrome tumor lysis syndrome acute lymphoblastic leukemia childhoodDiffuse alveolar damagechildhoodCreatininebusiness.industrylcsh:Rlcsh:RJ1-570lcsh:Pediatricsacute respiratory distress syndromemedicine.diseaseTumor lysis syndromemedicine.anatomical_structurechemistryImmunologyUric acidmedicine.symptomtumor lysis syndromeComplicationbusinessWeight gainPediatric Reports
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Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre1…

2021

Purpose: To investigate the possible association between ventilatory settings on the first day of invasive mechanical ventilation (IMV) and mortality in patients admitted to the intensive care unit (ICU) with severe acute respiratory infection (SARI). Materials and methods: In this pre-planned sub-study of a prospective, multicentre observational study, 441 patients with SARI who received controlled IMV during the ICU stay were included in the analysis. Results: ICU and hospital mortality rates were 23.1 and 28.1%, respectively. In multivariable analysis, tidal volume and respiratory rate on the first day of IMV were not associated with an increased risk of death; however, higher driving pr…

ARDSSoins intensifs réanimationmedicine.medical_treatmentAirway pressuresPEEP positive end-expiratory pressureCritical Care and Intensive Care Medicinelaw.inventionHypoxemiaCohort StudiesPositive-Pressure RespirationMechanical ventilationSARI severe acute respiratory infectionlawHospital MortalityProspective StudiesIQR interquartile rangesProspective cohort studyRCT randomized controlled trialTidal volumeSOFA Sequential Organ Failure AssessmentSAPS Simplified Acute Physiology ScoreIntensive care unitVCV volume-controlled ventilationHIV human immunodeficiency virusIntensive Care UnitsIC GLOSSARI Intensive Care Global Study on Severe Acute Respiratory Infectionmedicine.symptomCohort studyLOS length of staymedicine.medical_specialtyVt tidal volumeCOPD Chronic obstructive pulmonary diseaseNYHA New York Heart Association.PCV pressure-controlled ventilationArticleInternal medicineICU Intensive Care UnitSIMV Synchronized intermittent mandatory ventilationmedicineTidal VolumeHumansDP driving pressurePEEPARDS acute respiratory distress syndromeMechanical ventilationbusiness.industryOdds ratioPneumoniaPlateau pressuremedicine.diseaseRespiration ArtificialVILI ventilator induced lung injuryCI confidence intervalOR odds ratioIMV invasive mechanical ventilationCPAP continuous positive airway pressureARDSbusinessSD standard deviationECMO extracorporeal membrane oxygenationPBW predicted body weightPplat plateau pressure
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Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

2020

Abstract Background Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19. The aim of this systematic review was to describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy and safety. Methods MEDLINE, PubMed, EMBASE, pre-print repositories (bioRxiv and medRxiv) and two trial Registries were searched for studies on the use of tocilizumab in COVID-19 or SARS-CoV-2 infection, viral pneumonia, and/or sepsis until 20th June 2020. Results We identified 3 indirect pre-clinical studies and 28 clinical studies including 5776 patients with COVID-19 (13 with a comparison group,…

Coronavirus COVID-19 Pneumonia SARS-CoV-2 TocilizumabGCA Giant cell arteritispJIA Pediatric juvenile idiopathic arthritislaw.inventionchemistry.chemical_compound0302 clinical medicineRandomized controlled triallawMedicine030212 general & internal medicineClinical efficacyCPAP Continuous positive airway pressureCOVID-19 Coronavirus disease 2019IDSA Infectious Diseases Society of AmericaRA Rheumatoid arthritisTocilizumabIMV Invasive mechanical ventilationsJIA Juvenile idiopathic arthritisAIFA Agenzia Italiana del FarmacoPulmonary and Respiratory Medicinemedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MEDLINEAntibodies Monoclonal HumanizedNIH U.S. National Institutes of HealthArticleWHO World Health OrganizationSIMIT Italian Society of Infectious and Tropical disease03 medical and health sciencesTocilizumabARDS Acute respiratory distress syndromeAnimalsHumansIn patientIntensive care medicineTocilizumab ; COVID-19 ; Pneumonia ; SARS-CoV-2 ; Coronaviruslcsh:RC705-779business.industryCRS CAR-T cell-induced cytokine release syndromeInterleukin-6SARS-CoV-2NIV Noninvasive mechanical ventilationTNF Tumor necrosis factorCOVID-19Pneumonialcsh:Diseases of the respiratory systemCOVID-19 Drug TreatmentClinical trialCoronavirus030228 respiratory systemchemistrybusinessICTRP International Clinical Trials Registry PlatformPulmonology
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Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute resp…

2022

Contains fulltext : 252214.pdf (Publisher’s version ) (Open Access) BACKGROUND: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. METHODS: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to defi…

MaleSociodemographic FactorsRespiration Artificial/methodsARDS ; mechanical ventilationSeverity of Illness IndexNOSettore MED/41 - ANESTESIOLOGIA80 and overTidal VolumeHumansHospital MortalityProspective Studiesddc:610Developing CountriesAgedHospital Mortality/trendsAged 80 and overDeveloped Countries/statistics & numerical dataDeveloping Countries/statistics & numerical dataRespirationDeveloped CountriesArticlesGeneral Medicineacute respiratory distress syndromeLength of StayMiddle AgedRespiration ArtificialIntensive Care UnitsObservational Studies as Topiclnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]Length of Stay/statistics & numerical dataArtificialIntensive Care Units/statistics & numerical dataIncomeFemaleARDS
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Measles and Secondary Hemophagocytic Lymphohistiocytosis

2012

To the Editor: We found interesting the article by Lupo et al. about a case of fatal measles in an immunocompetent 29-year-old woman (Fatal measles without rash in immunocompetent adult, France; http://dx.doi.org/10.3201/eid1803.111300). Perhaps, however, the possible diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH) should also have been considered in that setting. HLH is a potentially fatal hyperinflammatory syndrome characterized by histiocyte proliferation and hemophagocytosis. HLH may be inherited (i.e., primary, familial, generally occurring in infants) or may occur at any age secondary to infection, malignancy, or rheumatologic disease. Secondary HLH is determined accor…

Microbiology (medical)Secondary Hemophagocytic LymphohistiocytosisLetterEpidemiologylcsh:Medicinerashacute lymphocytic leukemiaMeaslesArticlelcsh:Infectious and parasitic diseasespancytopeniadeathhemic and lymphatic diseasesAcute lymphocytic leukemiamedicineHumanspneumoniaviruseslcsh:RC109-216Letters to the EditorHistiocyteCytopeniahemophagocytosisbusiness.industrylcsh:RExanthemaacute respiratory distress syndromemedicine.diseasesecondary hemophagocytic lymphohistiocytosisPancytopeniaPneumoniaInfectious DiseasesImmunologyFemaleFranceHemophagocytosisbusinessMeaslesEmerging Infectious Diseases
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Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries

2018

Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteris…

MaleARDSInternationality[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]traqueostomíaCritical Care and Intensive Care MedicineSeverity of Illness IndexCohort StudiesPropensity-matched analysi0302 clinical medicineTracheostomyestudios prospectivosEpidemiologyAcute respiratory distress syndrome (ARDS)030212 general & internal medicineProspective Studiespuntuación de propensión10. No inequalityProspective cohort studyestudios de cohortesmediana edadancianoRespiratory Distress SyndromerespiraciónRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidMiddle Aged3. Good healthIntensive Care UnitsCohortArtificialCritical IllneFemaleAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; Ventilation; Aged; Cohort Studies; Critical Illness; Female; Humans; Intensive Care Units; Internationality; Male; Middle Aged; Propensity Score; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Severity of Illness Index; TracheostomyCohort studyHumanAdultmedicine.medical_specialtyCritical IllnessIntensive Care UnitSocio-culturaleunidades de cuidados intensivosenfermedad críticaPropensity-matched analysis03 medical and health sciencesAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; VentilationSeverity of illnessSettore MED/41 - ANESTESIOLOGIAmedicineHumansíndice de gravedad de la enfermedadPropensity ScoreAgedbusiness.industryResearchRespiratory Distress Syndrome Adultinternacionalidadlcsh:RC86-88.9medicine.diseaseR1Respiration ArtificialVentilationProspective Studie030228 respiratory systemPropensity score matchingEmergency medicineICUObservational studyCohort Studiebusiness
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Stratification for Identification of Prognostic Categories In the Acute RESpiratory Distress Syndrome (SPIRES) Score.

2021

OBJECTIVES: To develop a scoring model for stratifying patients with acute respiratory distress syndrome into risk categories (Stratification for identification of Prognostic categories In the acute RESpiratory distress syndrome score) for early prediction of death in the ICU, independent of the underlying disease and cause of death. DESIGN: A development and validation study using clinical data from four prospective, multicenter, observational cohorts. SETTING: A network of multidisciplinary ICUs. PATIENTS: One-thousand three-hundred one patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN …

AdultMalemedicine.medical_specialtyOrgan Dysfunction ScoresPsychological interventionMEDLINECritical Care and Intensive Care MedicineLogistic regressionSeverity of Illness IndexstratificationInternal medicinemedicineHumansProspective StudiesCause of deathAPACHEclinical trialsRespiratory Distress SyndromeReceiver operating characteristicbusiness.industryphenotypesscoring systemacute respiratory distress syndromeMiddle AgedPrognosisRespiration ArtificialIntensive Care UnitsROC CurveSpainArea Under CurveCohortBreathingoutcomeObservational studyFemalebusinessCritical care medicine
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Acute respiratory distress syndrome in traumatic brain injury: how do we manage it?

2017

Abstract: Traumatic brain injury (TBI) is an important cause of morbidity and mortality worldwide. TBI patients frequently suffer from lung complications and acute respiratory distress syndrome (ARDS), which is associated with poor clinical outcomes. Moreover, the association between TBI and ARDS in trauma patients is well recognized. Mechanical ventilation of patients with a concomitance of acute brain injury and lung injury can present significant challenges. Frequently, guidelines recommending management strategies for patients with traumatic brain injuries come into conflict with what is now considered best ventilator practice. In this review, we will explore the strategies of the best …

Pulmonary and Respiratory Medicinemedicine.medical_specialtyARDSTraumatic brain injurymedicine.medical_treatmentReview ArticleLung injury03 medical and health sciencesAcute respiratory distress syndrome (ARDS); Extra corporeal membrane oxygenation (ECMO); Positive end expiratory pressure (PEEP); Traumatic brain injury (TBI); Pulmonary and Respiratory Medicine0302 clinical medicineTraumatic brain injury (TBI); acute respiratory distress syndrome (ARDS); extra corporeal membrane oxygenation (ECMO); positive end expiratory pressure (PEEP)medicineExtracorporeal membrane oxygenationTraumatic brain injury (TBI)Intensive care medicinePositive end-expiratory pressureMechanical ventilationpositive end expiratory pressure (PEEP)Lungbusiness.industryextra corporeal membrane oxygenation (ECMO)acute respiratory distress syndrome (ARDS)030208 emergency & critical care medicinemedicine.diseaseProne positionmedicine.anatomical_structurebusiness030217 neurology & neurosurgeryJournal of thoracic disease
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